Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance.

نویسندگان

  • A Bauernfeind
  • I Stemplinger
  • R Jungwirth
  • H Giamarellou
چکیده

The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of Citrobacter freundii. The blaCMY-2 gene possibly was translocated onto a plasmid of C. freundii which spread to K. pneumoniae.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 40 1  شماره 

صفحات  -

تاریخ انتشار 1996